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Concurrent severe pulmonary tuberculosis with Evans syndrome: a case report with literature review.

Authors :
Pan, Xiao-hong
Xu, Jie-kun
Pan, Lei
Wang, Cai-hong
Huang, Xiao-qing
Qiu, Jun-ke
Ji, Xiao-bo
Mao, Min-jie
Source :
BMC Infectious Diseases. Dec2022, Vol. 22 Issue 1, p1-12. 12p.
Publication Year :
2022

Abstract

<bold>Background: </bold>Tuberculosis is a bacterial infection involving multiple organs and systems. Its hematological presentation mainly includes anemia and leukocytosis. Evans syndrome is a rare autoimmune disease characterized by autoimmune hemolytic anemia, immune thrombocytopenia, and neutropenia, with positive results for the direct Coombs test and platelet antibodies. The cooccurrence of tuberculosis and Evans syndrome is rarely reported.<bold>Case Presentation: </bold>A 69-year-old female presented with a fever and shortness of breath. Her chest computerized tomography scan showed extensive miliary nodules in the bilateral lung fields. She rapidly developed respiratory failure that required endotracheal intubation and mechanical ventilation. The acid-fast bacilli sputum smear results indicated a grade of 3+. Later on, blood testing revealed hemolytic anemia, a positive direct Coombs test result, and the presence of the platelet antibody IgG. This patient was diagnosed as having disseminated pulmonary tuberculosis and Evans syndrome. She successfully recovered after treatment with antituberculosis drugs and glucocorticoids.<bold>Conclusions: </bold>Tuberculosis can occur together with Evans syndrome. Affected patients should receive both antituberculosis and immunosuppressive drugs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712334
Volume :
22
Issue :
1
Database :
Academic Search Index
Journal :
BMC Infectious Diseases
Publication Type :
Academic Journal
Accession number :
157449730
Full Text :
https://doi.org/10.1186/s12879-022-07512-1