三阴乳腺癌新辅助化疗的预后与 Ki-67、TOPK 的表达情况相关性研究.

Objective: To analysis the correlation of Ki-67, TOPK expression of neoadjuvant chemotherapy(NACT) in triple-negative breast cancer (TNBC) with prognosis. Methods: 90 TNBC patients admitted in our hospital from March 2014 to June 2016 were collected as research objects, the expression of Ki-67 and TOPK in tumor tissues were detected by immunohistochemistry method, the correlation of Ki-67 and TOPK expression with pathological characteristics were analysed, the survival analysis were analyzed by Cox proportional hazards regression model rognosis, the independent risk factors for prognosis were analysed. Results: In terms of treatment, 91.11 % (82/90) of patients received ≥ 4 cycles of NACT, 84.44 % (76/90) of patients received surgery, and post-operative pCR was 22.22 % (20/90) and ORR was 75.56 % (68/90). During the 5-year follow-up, 8 of the 90 patients died (6 died of TNBC and 2 died of other causes), and 2 were lost to follow-up. The positive expression rates of Ki-67 and TOPK were decreased after NACT(P＜0.05). There were significant differences between the positive and negative expression of KI-67 and TOPK in different TNM stages and lymph node metastasis (P＜0.05). The progression-free survival (PFS) and overall survival (OS) of patients with Ki-67 and TOPK positive expression was shorter than negative expression (P＜0.05). The prognosis of TNBC patients were independently associated with TNM stage, lymph node metastasis, positive expression of Ki-67 and TOPK (P＜0.05). Conclusions: The expression of Ki-67 and TOPK in tissues was closely correlated with pathological characteristics and prognosis, which were independent risk fators for prognosis. [ABSTRACT FROM AUTHOR]