Synthesis, Crystal Structure, and Anticancer Activity of the Dinuclear Dibutyltin Complexes.

Dinuclear dibutyltin complexes {[2-O-C6H4(O)C=N-N=C(O)CPh2O](n-Bu2Sn)2}n (C1) and {[2-(3-O-C8H6)(O)C=N-N=C-2-(3-O-C8H6)]2(n-Bu2Sn)2}n (C2) have been synthesized and characterized by IR, 1H, 13C, and 119Sn NMR spectra, HRMS, elemental analysis, and thermal stability analysis. Their crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes have been evaluated by the CCK8 method against three human cancer cell lines (MCF-7, NCI-H460, and HepG2), and the complexes have exhibited high activity against MCF-7 and HepG2. [ABSTRACT FROM AUTHOR]