Aligning mealtimes to live longer.

The article reports that Calorie restriction (CR) involves chronic reduction of energy intake without inducing malnutrition. Topics CR extends life span in multiple animal models and reduces the risk of age-associated disorders which arise from metabolic dysfunction and inflammation; and reducing energy intake, can improve health and increase life span in model organisms contribution of fasting and timing of calorie-reduced meals to the efficacy of CR, as estimated by life-span extension.