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Impact of low-carbohydrate diet on serum levels of leptin and adiponectin levels: a systematic review and meta-analysis in adult.
- Source :
-
Journal of Diabetes & Metabolic Disorders . Jun2022, Vol. 21 Issue 1, p979-990. 12p. - Publication Year :
- 2022
-
Abstract
- Background: Various studies have evaluated the effects of low-carbohydrate diet (LCD) on serum concentrations of adipokines. Although the association between LCD and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent. Objective: The purpose of this study was to systematically evaluate the effect of LCD on serum levels of leptin and adiponectin. Design: Electronic databases were retrieved in PubMed, Embase, Scopus and Web of Science to search relevant publications. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by the random-effect model. Cochrane Q test and I2 statistic were used to test heterogeneity. Subgroup analysis and meta-regression were applied to assess possible sources of heterogeneity. Results: A total of thirty-five articles were included in final analysis. Meta-analysis results revealed no statistical association between LCD and adiponectin concentration (WMD: 0.32 ng/ml, 95% CI: - 0.02, 0.66, p=0.062). Subgroup analysis showed that LCD increased adiponectin concentration in subjects under 45 years old and in studies with long term duration intervention. Also, did not observe a significant effect from the LCD on serum concentration of leptin (WMD: - 0.77 ng/ml, 95% CI: -3.15, 1.61, P=0.409). Subgroup analysis did not show any new information. The results of this study did not support the evidence for the positive effects of LCD on serum leptin and adiponectin levels. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22516581
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Diabetes & Metabolic Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 157263115
- Full Text :
- https://doi.org/10.1007/s40200-021-00952-7