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Risk factors for incidence of dementia in primary care practice: a retrospective cohort study in older adults.
- Source :
-
Family Practice . Jun2022, Vol. 39 Issue 3, p406-412. 7p. - Publication Year :
- 2022
-
Abstract
- <bold>Background: </bold>The dementias are long-term, chronic conditions caused by progressive neurological degeneration. Current literature suggests that cardiovascular disease risk factors may contribute to the onset of dementia; however, evidence of these associations is inconsistent.<bold>Objectives: </bold>This study aimed to examine the impact of risk factors on dementia onset in older adults diagnosed and managed in Canadian primary care settings.<bold>Methods: </bold>A retrospective cohort study was employed utilizing electronic medical records data in the Canadian Primary Care Sentinel Surveillance Network (CPCSSN). Patients aged 65+ years with no dementia diagnosis at baseline who were followed from 2009 to 2017 with a run-in year to exclude existing undiagnosed dementia cases. Multivariate Cox proportional hazard models were used to estimate risk.<bold>Results: </bold>Age was associated with an increased incidence risk of dementia in both examined age groups: 65-79 years (13%) and 80+ years (5%). History of depression increased dementia risk by 38% and 34% in the age groups. There were significant associations with lower social deprivation area quintile, smoking history, osteoarthritis, and diabetes mellitus in patients aged 65-79 years but not in those aged 80+ years. Sex, hypertension, obesity, dyslipidemia, and the use of antihypertensive medications and statins were not associated with risk of incident dementia diagnosis.<bold>Conclusions: </bold>The association between chronic health conditions and dementia onset is complicated. Primary care electronic medical record data might be useful for research in this topic, though follow-up time is still relatively short to observe a clear causal relationship. Future studies with more complete data may provide evidence for dementia preventive strategies within primary care practice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02632136
- Volume :
- 39
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Family Practice
- Publication Type :
- Academic Journal
- Accession number :
- 157126883
- Full Text :
- https://doi.org/10.1093/fampra/cmab168