Mast cell‐pain connection in eosinophilic esophagitis.

Abbreviations CCHMC Cincinnati Children's Hospital Medical Center CEGIR Consortium of Eosinophilic Gastrointestinal Disease Researchers EDP eosinophilic esophagitis diagnostic panel EoE eosinophilic esophagitis HPF high-power field MC Mast cells; PRO, Patient-reported outcome EEsAI eosinophilic esophagitis activity index PEESS Pediatric Eosinophilic Esophagitis Symptom Scores HSS EoE Histology Scoring System EREFS EoE endoscopic reference score CONFLICT OF INTEREST M.E.R. is a consultant for Pulm One, Spoon Guru, Allakos, ClostraBio, Serpin Pharm, Celgene, Shire, AstraZeneca, GlaxoSmithKline, Allakos, Adare, Regeneron, and Novartis and has an equity interest in the first five, as well as royalties from reslizumab (Teva Pharmaceuticals) and UpToDate. Mast cells (MCs) are involved in allergy, including EoE,2 and neuromodulation.3 MCs reside in peripheral tissue and communicate with nearby structures, including nerve endings. We divided active EoE into four quartiles by using I CPA3 i + I HPGDS i sum as a MC count surrogate marker; the highest and lowest quartiles represented MC-high and MC-low, respectively. [Extracted from the article]