Lack of analytical interference of dydrogesterone in progesterone immunoassays.

The present I in vitro i investigation therefore was designed to test for potential interference of DYD/DHD with routinely and widely spread used P4 assays over a range of concentrations of DYD/DHD and P4. Keywords: -dihydrodydrogesterone; cross-reaction; Duphaston; dydrogesterone; interference; progesterone immunoassay EN -dihydrodydrogesterone cross-reaction Duphaston dydrogesterone interference progesterone immunoassay 1039 1045 7 05/26/22 20220601 NES 220601 Introduction Progesterone (P4) is an endogenous steroid hormone which is mainly secreted by the corpus luteum, a temporary endocrine structure in the ovary, and by the placenta during pregnancy. Graph: Figure 2: Graphical presentation of the recovery of progesterone (P4) in the samples with H(igh), M(edium), and L(ow) P4 concentration after addition of DYD/DHD at H(igh) and M(edium) concentration in the seven tested assay. For each sample to which DYD and DHD were added, the percent recovery was calculated against the corresponding P4 plasma sample to which no DYD and DHD was added. [Extracted from the article]