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Stimuli-sensitive drug delivery systems for site-specific antibiotic release.
- Source :
-
Drug Discovery Today . Jun2022, Vol. 27 Issue 6, p1698-1705. 8p. - Publication Year :
- 2022
-
Abstract
- • The stimuli leading to drug release can be either external or internal. • Nanoparticles are promising agents for targeted stimuli-dependent antibiotic drugs delivery. • Targeted antibiotic release at desired site minimizes the resistance and side effects associated with systematic release of drug(s). Site-specific delivery of antibiotics has always been a high-priority area in pharmaceutical research. Conventionally used antibiotics suffer several limitations, such as low accumulation and penetration in diseased cells/tissues, limited bioavailability of drugs, drug resistance, and off-target toxicity. To overcome these limitations, several strategies have been exploited for delivering antibiotics to the site of infection, such as the use of stimuli-responsive antibiotic delivery systems, which can release antibiotics in a controlled and timely fashion. These stimuli can either be exogenous (light, magnetism, ultrasound, and electrical) or endogenous (pH, redox reactions, and enzymatic). In this review, we present a summary of recent developments in the field of stimuli-based targeted drug delivery systems for the site-specific release of antibiotics. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DRUG delivery systems
*ANTIBIOTICS
*DRUG bioavailability
Subjects
Details
- Language :
- English
- ISSN :
- 13596446
- Volume :
- 27
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Drug Discovery Today
- Publication Type :
- Academic Journal
- Accession number :
- 157033603
- Full Text :
- https://doi.org/10.1016/j.drudis.2022.02.014