2022 Beijing Winter Olympics: Spotlight on Cardiac Metabolism.

Keywords: efficiency; exercise performance; performance-enhancing substances; trimetazidine EN efficiency exercise performance performance-enhancing substances trimetazidine 1561 1562 2 05/23/22 20220524 NES 220524 The world is full of surprises. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Inhibition of fatty acid oxidation by trimetazidine (TMZ) enhances ATP production from glucose oxidation. [Extracted from the article]