Predictive Factors for Local Relapse in Breast Cancer Patients after Surgery Breast Cancer Surgery and Local Relapse.

Background and objectives: We aimed to identify the possible risk factors that may affect local relapse after conservative surgery or modified radical mastectomy for breast cancer. Methods: We conducted a retrospective observational study of breast cancer patients treated with conservative surgery or modified radical mastectomy between 2012 and 2019. All analyses were undertaken using Statistical Package for the Social Sciences (SPSS) version 23.0. Results: A total of 70 women were included in our study. Of them, 29 women were =50, and 22 women had a tumor size of =20. Negative lymph node involvement was noted in 54 women (77.1%) and multifocality in 33 women (47.1%). The commonest histological type was ductal (87.1%). Positive estrogen, progesterone, and HER2 receptors were reported in 84%, 70%, and 6%, respectively. Local relapse occurred in only sevenpatients (10%); 6 patients had it in the first 24 months. The mean time for recurrence-free was 47.06 ± 22.92 months (range= 9 to 79 months). There was a statistically significant association between local relapse and tumor size (p= 0.029), clinical lymph node involvement (p= 0.043), multifocality (p= 0.046), neoadjuvant chemotherapy (p= 0.028), metastasis (p= 0.019), and positive margins (p= 0.006). There was a statistically significant relationship between local relapse and estrogen, progesterone, and HER2 receptors (all p<0.05). Conclusion: A proper monitoring of breast cancer patients is critical to prevent local relapse after surgical operations. Determining the risk factors may provide a proper management plan, good clinical outcome, and therefore preventing tumor recurrence. [ABSTRACT FROM AUTHOR]