肾动脉栓塞术联合肾上腺色腙片对急性肾出血患者凝血功能、肾功能的影响.

OBJECTIVE: To probe into the effects of renal artery embolization combined with Adrenal hydrazone tablets on coagulation function and renal function in patients with acute renal hemorrhage. METHODS: A total of 61 patients with acute renal hemorrhage admitted into the Ninth People’ s Hospital Affiliated to Shanghai Jiaotong University School of Medicine from Sept. 2019 to Sept. 2021 were selected and divided into the single treatment group ( n = 30) and the combined treatment group (n = 31) via random number table. The single treatment group was treated with renal artery embolization, while the combined treatment group received renal artery embolization combined with Adrenal hydrazone tablets. The renal function of two groups was compared. Plasma prothrombin time (PT), activated partial thrombin time ( APTT) and fibrinogen ( FIB) levels were determined by immunoturbidimetry, and tumor necrosis factor α (TNF-α), interleukin ( IL)-1 and IL-22 levels were determined by enzyme-linked immunosorbent assay. The treatment effects and incidence of complications were observed. RESULTS: After treatment, the levels of hematocrit and hemoglobin in the combined treatment group were higher than those in the single treatment group, and the heart rate was lower than that in the single treatment group, with statistically significant differences (P<0. 05). After treatment, the levels of serum creatinine, 24 h urine protein and blood urea nitrogen in the combined treatment group were lower than those in the single treatment group, the differences were statistically significant (P< 0. 05). After treatment, PT and APTT in the combined treatment group were longer than those in the single treatment group, and the levels of FIB, TNF-α, IL-1 and IL-22 were lower than those in the single treatment group, the differences were statistically significant ( P < 0. 05 ). The total effective rate in the combined treatment group was 96. 77% (30 / 31), higher than 76. 67% (23 / 30) in the single treatment group; the incidence of complications in the combined treatment group was 3. 23% (1 / 31), lower than 20. 00% (6 / 30) in the single treatment group, the difference was statistically significant ( P < 0. 05). CONCLUSIONS: Renal arterial embolization combined with Adrenal hydrazone tablets in the treatment of acute renal hemorrhage can improve the renal function and the coagulation function, effectively regulate the inflammatory reaction, with remarkable therapeutic effects. [ABSTRACT FROM AUTHOR]