Cardiac fibroblast heterogeneity and dynamics through the lens of single-cell dual 'omics.

This editorial refers to 'Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes' by L.Wang I et al. i , doi: 10.1093/cvr/cvab134. Main cell lineages identified from integrative analyses including endothelial cells, pericytes, fibroblasts, and immune cells. A significant strength of the Wang I et al i . study is the integration of single-cell transcriptomics data with single nuclear chromatin accessibility data generated using the assay for transposase accessible chromatin using sequencing (ATAC-seq). [Extracted from the article]