High endemicity of Q fever in French Guiana: A cross sectional study (2007–2017).

Q fever (QF) is a zoonosis caused by Coxiella burnetii (Cb). French Guiana (FG) had a high incidence but no data have been published since 2006. The objective of this study was to update the incidence and epidemiological data on QF in FG. A retrospective study of all FG Q fever serodiagnosis between 2007 and 2017 was carried out. Among the 695 patients included, the M/F sex-ratio was 2.0 and the median age of 45.3 years (IQR 33.7–56.3). The annual QF incidence rate was 27.4 cases (95%CI: 7.1–47.7) per 100,000 inhabitants ranging from 5.2 in 2007 to 40.4 in 2010. Risk factors associated with Q fever compared to general population were male gender, being born in mainland France an age between 30 to 59 years-old and a residence in Cayenne and surroundings. The incidence of QF in FG remains high and stable and the highest in the world. Author summary: We present here a study showing the exceptional nature of the incidence of Q fever in Guyana. Indeed, this zoonosis due to the bacterium Coxiella burnetii, is a real public health problem in French Guiana, a French ultra-marine territory located in the North East of South America. The study found an endemic state with a stable incidence between 2010 and 2017 around 25–30 cases per 100,000 inhabitants per year. More than 90% of cases are concentrated in the territory's capital, Cayenne, and its surroundings. The risk factors for Q fever are being male, being between 30 and 59 years old, which are risk factors found elsewhere, but also living in Cayenne and its surroundings and being born in mainland France or Europe. [ABSTRACT FROM AUTHOR]