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Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 5/17/2022, p1-8. 8p. 1 Diagram, 1 Chart, 7 Graphs. - Publication Year :
- 2022
-
Abstract
- Background. Diabetes is a metabolic disease linked to multiple comorbidities, such as low-grade inflammation. β-pinene, a monoterpene commonly found in aromatic plants, is endowed with anti-inflammatory effect and this fact lead us to investigate the possible hypoglycemic, hypolipidemic and anti-inflammatory effects of the monoterpene in the alloxan-induced diabetes experimental model. Methods. Male Wistar rats (200–250 g) were treated orally with β-pinene (25, 50, 100, and 200 mg/kg) or glibenclamide (5 mg/kg), for seven consecutive days. Diabetes was induced by alloxan (40 mg/kg) through the penile vein. On the seventh day of treatment, blood samples were collected for biochemical analysis. The anti-inflammatory effect of β-pinene was evaluated using the carrageenan-induced paw edema model, followed by the carrageenan-induced peritonitis. Results. The treatment with β-pinene decreased plasma glucose, triglyceride, VLDL, LDL, and HDL levels, when compared to those of the control group. In addition, the association β-pinene 10 mg/kg + glibenclamide 2 mg/kg significantly decreased blood glucose, total cholesterol, and triglyceride level. Finally, oral treatment with β-pinene reduced carrageenan-induced paw edema and leukocyte migration in the peritoneum. Taken together, our results indicate that β-pinene shows hypoglycemic and hypolipemic effects, which may involve some common mechanisms of glibenclamide. Besides, the monoterpene presented an anti-inflammatory action in diabetic rats that needs further investigation in order to clarify such effect and its correlation with the alterations observed in plasma parameters of β-pinene-treated diabetic rats. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOLOGICAL models
*TRIGLYCERIDES
*TERPENES
*ESSENTIAL oils
*HYPOGLYCEMIC sulfonylureas
*INFLAMMATION
*ANIMAL experimentation
*HETEROCYCLIC compounds
*LEUCOCYTES
*DIABETES
*LOW density lipoproteins
*TREATMENT effectiveness
*RATS
*HYPOGLYCEMIA
*DESCRIPTIVE statistics
*GLUCOSE
*MOLECULAR structure
*HIGH density lipoproteins
*LIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 156911293
- Full Text :
- https://doi.org/10.1155/2022/8173307