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Discovery of New Bohemamines and Synthesis of Methylene‐Bridged Chimeric Derivatives through Natural Product Chimera Strategy.
- Source :
-
Chinese Journal of Chemistry . Jun2022, Vol. 40 Issue 12, p1413-1421. 9p. - Publication Year :
- 2022
-
Abstract
- Comprehensive Summary: Five new pyrrolizidine alkaloids, bohemamines J—N (1—5), were isolated from Streptomyces sp. CPCC 200497. Their structures were assigned based on detailed spectroscopic analysis and semisynthesis. Bohemamine J (1) possesses a new chimeric skeleton derived from bohemamine A (6) and phenylacetaldehyde. Inspired by the nonenzymatic formation mechanism of the methylene‐bridged dimers isolated from this strain, we synthesized a series of chimeric derivatives (8, 9, and 12—23) through natural product chimera strategy. Compounds 13, 15, 19, and 21 showed significant antioxidant activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NATURAL products
*PYRROLIZIDINES
*DIMERS
*STREPTOMYCES
Subjects
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 40
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 156900811
- Full Text :
- https://doi.org/10.1002/cjoc.202200034