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Topical Dosage Formulation of Lyophilized Philadelphus coronarius L. Leaf and Flower: Antimicrobial, Antioxidant and Anti-Inflammatory Assessment of the Plant.

Authors :
Pető, Ágota
Kósa, Dóra
Haimhoffer, Ádám
Nemes, Dániel
Fehér, Pálma
Ujhelyi, Zoltán
Vecsernyés, Miklós
Váradi, Judit
Fenyvesi, Ferenc
Frum, Adina
Gligor, Felicia Gabriela
Vicaș, Laura Grațiela
Marian, Eleonora
Jurca, Tunde
Pallag, Annamaria
Muresan, Mariana Eugenia
Tóth, Zoltán
Bácskay, Ildikó
Source :
Molecules. May2022, Vol. 27 Issue 9, p2652-2652. 18p.
Publication Year :
2022

Abstract

Philadelphus coronarius is a versatile plant and its use in folk medicine has a long tradition; however, scientifically, the medical utilization of the herb is a less explored research field. The aim of our study was to identify and determine the quantity of the bioactive compounds of both the leaf and the flower and prepare a lyophilized product of them, from which medical ointments were formulated, since the topical application of P. coronarius has also not been studied. In vitro drug release, texture analysis and biocompatibility experiments were carried out, as well as the investigation of microbiological, antioxidant and anti-inflammatory properties. According to our results the composition and the selected excipients of the ointments have a great impact on the drug release, texture and bioavailability of the preparation. During the microbiological testing, the P. coronarius leaf was effective against Escherichia coli and Staphylococcus aureus, but it did not significantly decrease IL-4 production when it was tested on HaCaT cells. P. coronarius is a promising herb, and its topical application in antimicrobial therapy can be a useful addition to modern medical therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
27
Issue :
9
Database :
Academic Search Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
156876614
Full Text :
https://doi.org/10.3390/molecules27092652