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KI/K2S2O8 Mediated Cascade C(sp3)−H/C(sp2)−H Thiolation for the Synthesis of Multi‐Substituted Thiazoles.
- Source :
-
European Journal of Organic Chemistry . 5/6/2022, Vol. 2022 Issue 17, p1-5. 5p. - Publication Year :
- 2022
-
Abstract
- Thiazole and carbonyl often act as core functional or regulative moieties in biological molecules as well as optical materials. Designing and synthesis of carbonyl‐containing thiazoles are of great importance for related fields, hence, a simple and practical method was developed using commercially xanthates, benzylamine, and readily available alkynones as substrates. The reaction was achieved using one‐pot Michael addition and cascade iodine mediated C−H thiolation under mild conditions. This method features a broad substrate scope with high yield. Remarkably, the obtained carbonyl substituted thiazoles bearing electronic‐donating substituents exhibit promising performance for aggregation‐induced emission (AIE) and have been successfully used in biological imaging. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2022
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 156868868
- Full Text :
- https://doi.org/10.1002/ejoc.202200161