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Salicornia herbacea Aqueous Extracts Regulate NLRP3 Inflammasome Activation in Macrophages and Trophoblasts.
- Source :
-
Journal of Medicinal Food . May2022, Vol. 25 Issue 5, p503-512. 10p. - Publication Year :
- 2022
-
Abstract
- Salicornia herbacea L. (Chenopodiaceae), an edible salt marsh plant with anti-inflammatory effects, was examined in macrophages and trophoblasts whether it modulates NLRP3 inflammasome activity. Pretreatment and delayed treatment of S. herbacea extract (SHE) in bone marrow-derived macrophages (BMDMs) reduced the activity of NLRP3 inflammasome induced by lipopolysaccharide (LPS) and adenosine triphosphate stimulation and downregulated interleukin (IL)-1β production. SHE also inhibited pyroptotic cell death, the adaptor molecule apoptosis-associated speck-like protein containing a CARD (ASC), oligomerization, and speck by NLRP3 inflammasome activity in BMDM. Similarly, SHE decreased the mRNA expression of NLRP3, ASC, IL-1β, and IL-6 in the LPS-stimulated human trophoblast cell line, Swan 71 cells. In addition, SHE inhibited the production of IL-6 and IL-1β and decreased the expression of cyclooxygenase-2 and prostaglandin E2 in stimulated Swan 71 cells. Finally, 3,5-dicaffeoylquinic acid (3,5-DCQA), one of the components of S. herbacea, inhibited IL-1β produced by NLRP3 inflammasome activity. In conclusion, SHE downregulated the activity of the NLRP3 inflammasome in macrophages and trophoblasts. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLASTOCYST
*LIPOPOLYSACCHARIDES
*ADENOSINE triphosphate
*INTERLEUKINS
*CYCLOOXYGENASE 2
*PROSTAGLANDINS
*MEDICINAL plants
*TROPHOBLAST
*POLYPHENOLS
*ANTI-inflammatory agents
*ANIMAL experimentation
*NONSTEROIDAL anti-inflammatory agents
*SIGNAL peptides
*MACROPHAGES
*APOPTOSIS
*EDIBLE plants
*GENE expression
*MESSENGER RNA
*PLANT extracts
*CELL lines
*MICE
*CELL death
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1096620X
- Volume :
- 25
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Food
- Publication Type :
- Academic Journal
- Accession number :
- 156868270
- Full Text :
- https://doi.org/10.1089/jmf.2021.K.0154