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Patient-Reported Outcomes During Checkpoint Inhibition: Insight into Symptom Burden in Daily Clinical Practice.
- Source :
-
Journal of Pain & Symptom Management . Jun2022, Vol. 63 Issue 6, p997-1005. 9p. - Publication Year :
- 2022
-
Abstract
- <bold>Context: </bold>While praised for inducing durable anti-tumour responses, immune checkpoint inhibitors (ICI) also cause immune-related adverse events (irAEs) that can vary in severity and affect health-related quality of life (HRQL).<bold>Objectives: </bold>This study was performed to provide insight into the course of symptoms and the influence of irAEs on HRQL measured with the treatment-specific Utrecht Symptom Diary Immunotherapy (USD-I).<bold>Methods: </bold>In this observational cohort study, melanoma or non-small lung cancer (NSCLC) patients treated with PD(L)1-inhibitors between February 2016 and December 2018 were included. Data on symptoms, wellbeing and influence of side effects on HRQL were obtained using the patient-scored, treatment-specific USD-I, which was completed as part of routine care. Patients scored symptom intensity on a 0-10 numeric rating scale (NRS); NRSā„3 considered clinically relevant.<bold>Results: </bold>A total of 162 melanoma (55%) or NSCLC (45%) patients completed 1493 USDs (median seven per patient). Most common patient-reported clinically relevant symptoms were: inactivity, fatigue, pain, cough and sleeping problems. Symptom prevalence decreased during treatment. Patients generally reported a low influence of side effects on HRQL. A higher number of clinically relevant symptoms at a certain time point correlated with poorer wellbeing.<bold>Conclusions: </bold>These data illustrate that ICI-treatment is generally well tolerated. However, especially the number of clinically relevant symptoms can impact patients wellbeing. Systematic use of an ICI-tailored PROM could create a window to discuss symptoms in a structured way which may promote personalized care during treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08853924
- Volume :
- 63
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Pain & Symptom Management
- Publication Type :
- Academic Journal
- Accession number :
- 156810487
- Full Text :
- https://doi.org/10.1016/j.jpainsymman.2022.02.013