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Synthesis of Fluorine-Containing Analogues of Purine Deoxynucleosides: Optimization of Enzymatic Transglycosylation Conditions.

Authors :
Drenichev, M. S.
Dorinova, E. O.
Varizhuk, I. V.
Oslovsky, V. E.
Varga, M. A.
Esipov, R. S.
Lykoshin, D. D.
Alexeev, C. S.
Source :
Doklady Biochemistry & Biophysics. Apr2022, Vol. 503 Issue 1, p52-58. 7p.
Publication Year :
2022

Abstract

In this work, a comparative analysis of the conditions of transglycosylation reactions catalyzed by E. coli nucleoside phosphorylases was carried out, and the optimal conditions for the formation of various nucleosides were determined. Under the optimized conditions of transglycosylation reaction, fluorine-containing derivatives of N6-benzyl-2'-deoxyadenosine, potential inhibitors of replication of enteroviruses in a cell, were obtained starting from the corresponding ribonucleosides. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16076729
Volume :
503
Issue :
1
Database :
Academic Search Index
Journal :
Doklady Biochemistry & Biophysics
Publication Type :
Academic Journal
Accession number :
156790144
Full Text :
https://doi.org/10.1134/S1607672922020053