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Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging
- Source :
-
Brain Research . Jan2005, Vol. 1031 Issue 1, p125-128. 4p. - Publication Year :
- 2005
-
Abstract
- Abstract: Release of Ca2+ from intracellular Ca2+ stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca2+ source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potentials were recorded from CA3-CA1 synaptic contacts from hippocampal slices obtained from young (5–8 months) and aged (22–24 months) male Fischer 344 rats. Blockade of Ca2+-release from ICS by cyclopiazonic acid, thapsigargin, or ryanodine blocked LTD induction in aged rats. Impaired LTD was not simply due to a loss of a Ca2+ source. The idea that ICS may play prominent role in regulating synaptic modifiability through regulation of cell excitability and the timing of pre and postsynaptic activity is discussed. [Copyright &y& Elsevier]
- Subjects :
- *ALKALOIDS
*INSECTICIDES
*RYANODINE
*MICROBIAL metabolites
Subjects
Details
- Language :
- English
- ISSN :
- 00068993
- Volume :
- 1031
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 15671093
- Full Text :
- https://doi.org/10.1016/j.brainres.2004.10.023