Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion for Micro-Preemie Infants with Septic Shock. Is Extended Duration Better than Early Start? Comment to the Letter to the Editor of Nishizaki and Colleagues.

Nishizaki and colleagues [[1]] reported in the letter to the editor that prognosis of septic neonates in earlier PMX-DHP induction was better than that in later PMX-DHP induction. Although it is theoretically possible to extend the duration of PMX-DHP treatment in neonates, it will be practically difficult to perform longer treatment in neonates because of unstable hemodynamics during PMX treatment. The criterion for excluding PMX-DHP therapy for pediatric patients with septic shock is intracranial bleeding or tendency to bleed in general. [Extracted from the article]