睡眠质量与脑胶质瘤致病关系的探索性研究.

This study explores the risk factors for glioma, in order to provide a scientific basis for the further etiology research and prevention of glioma. Methods: A case-control study method was used. All the cases, who consist of 109 patients with pathologically diagnosed glioma, were recruited from the patients treated in the Beijing Tiantan Hospital Affiliated to the Capital Medical University and Beijing Shijitan Hosptial Affiliated to the Capital Medical University from June, 2017 to October, 2018. And controls of117 people. Study subjects were interviewed in the hospital ward, using a structured questionnaire administered by trained interviewers. The risk factors related to glioma were analysed by Logistic regression. Results: The results of unvariable analysis showed that there might has association between glioma and poorer sleep quality (OR=1.468, 95%CI:1.275-2.275), shorter sleep time (OR=1.797, 95%CI:1.070-3.015）, lower sleep efficiency （OR=2.992, 95% CI:2.259-3.964）, and Pittsburgh sleep scale total score (OR=1.180, 95% CI:1.093-1.272）, the results were statistically significant (P<0.05). Adding other exporse factors, the results of multi-logistic regression analysis results showed that there might has association between glioma and poorer sleep quality （OR=1.457, 95% CI: 1.060-2.002）, and lower sleep efficiency (OR=4.267, 95% CI: 2.634-6.914）, also the results were statistically significant (P<0.05). Conclusion: This study use a case-control study, through logistic regression analysis, found that worse sleep quality and low sleep efficiency might be positive to the occurence of glioma. As a pilot study, hoping can provide a scientific basis for the further etiology research and prevention of glioma. [ABSTRACT FROM AUTHOR]