Topographic distribution of gene expression and sinonasal inflammation in chronic rhinosinusitis without nasal polyposis.

Keywords: chromosome; cytokines; gene expression; inflammation; microarray; Rhinosinusitis; signalling pathways EN chromosome cytokines gene expression inflammation microarray Rhinosinusitis signalling pathways 719 722 4 04/29/22 20220501 NES 220501 Key Messages Extra-sinus nasal tissue has been used to support mechanistic statements for pathogenesis of CRSsNP. .001</td></tr></tbody></table> ht In the present investigation, although inflammation is present within both the nasal floor and ethmoid sinus of patients with CRSsNP, the inflammatory gene and pathway expression profiles manifest differently across the two subsites. There were 46 transcripts that were significantly different between the anterior ethmoid sinus mucosa and the floor of the nose using a cut-off of a >=4-fold change was implemented and presented (Gene Expression Omnibus contains the full dataset). These findings may provide useful insight into how sinus mucosa differs in its inflammatory response from nasal floor mucosa, while accounting for site-dependent differences in the inflammatory profile of patients with CRS. [Extracted from the article]