Palladium‐Catalyzed Chemoselective Borylation of (Poly)halogenated Aryl Triflates and Their Application in Consecutive Reactions.

This study reports the palladium‐catalyzed chemoselective borylation of (poly)halogenated aryl triflates with a reactivity order of C−Cl>C−OTf. A catalyst system comprising Pd(OAc)2 and SelectPhos (L1) enables a reaction with high reactivity and chemoselectivity. The consecutively chemoselective borylation reaction followed by the chemoselective intermolecular Suzuki‐Miyaura reaction can be performed using a one‐pot two‐step approach to synthesize unsymmetrical biaryl compounds containing the triflate moiety. The reaction can be scaled up to the gram scale without diminishing the yield and chemoselectivity. [ABSTRACT FROM AUTHOR]