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Definition of High-Risk Early Hormone-Positive HER2−Negative Breast Cancer: A Consensus Review.

Authors :
Garutti, Mattia
Griguolo, Gaia
Botticelli, Andrea
Buzzatti, Giulia
De Angelis, Carmine
Gerratana, Lorenzo
Molinelli, Chiara
Adamo, Vincenzo
Bianchini, Giampaolo
Biganzoli, Laura
Curigliano, Giuseppe
De Laurentiis, Michelino
Fabi, Alessandra
Frassoldati, Antonio
Gennari, Alessandra
Marchiò, Caterina
Perrone, Francesco
Viale, Giuseppe
Zamagni, Claudio
Zambelli, Alberto
Source :
Cancers. Apr2022, Vol. 14 Issue 8, p1898. 17p.
Publication Year :
2022

Abstract

Simple Summary: Breast cancer is one of the major causes of cancer-related morbidity and mortality in women worldwide. Despite recent improvements in adjuvant treatment of hormone receptor-positive/HER2−negative breast cancer, estimating the risk of relapse of breast cancer on an individual basis is still challenging. The IRIDE (high risk definition in breast cancer) working group was established with the aim of reviewing evidence from the literature to synthesize the current relevant features that predict hormone-positive/HER2−negative early breast cancer relapse. This work may guide clinicians in the practical management of hormone-positive/HER2−negative early breast cancers. Breast cancer is one of the major causes of cancer-related morbidity and mortality in women worldwide. During the past three decades, several improvements in the adjuvant treatment of hormone receptor-positive/HER2−negative breast cancer have been achieved with the introduction of optimized adjuvant chemotherapy and endocrine treatment. However, estimating the risk of relapse of breast cancer on an individual basis is still challenging. The IRIDE (hIGh Risk DEfinition in breast cancer) working group was established with the aim of reviewing evidence from the literature to synthesize the current relevant features that predict hormone-positive/HER2−negative early breast cancer relapse. A panel of experts in breast cancer was involved in identifying clinical, pathological, morphological, and genetic factors. A RAND consensus method was used to define the relevance of each risk factor. Among the 21 features included, 12 were considered relevant risk factors for relapse. For each of these, we provided a consensus statement and relevant comments on the supporting scientific evidence. This work may guide clinicians in the practical management of hormone-positive/HER2−negative early breast cancers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726694
Volume :
14
Issue :
8
Database :
Academic Search Index
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
156504598
Full Text :
https://doi.org/10.3390/cancers14081898