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Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men

Authors :
Gill, Jason M.R.
Al-Mamari, Ali
Ferrell, William R.
Cleland, Stephen J.
Packard, Chris J.
Sattar, Naveed
Petrie, John R.
Caslake, Muriel J.
Source :
Journal of the American College of Cardiology (JACC). Dec2004, Vol. 44 Issue 12, p2375-2382. 8p.
Publication Year :
2004

Abstract

Objectives: We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction. Background: Endothelial function is impaired after fat ingestion, and this may be related to rises in triglyceride concentrations. Exercise reduces postprandial triglyceride concentrations. Methods: Ten lean (waist <90 cm) and 10 centrally obese (waist >100 cm) middle-aged men each underwent two oral fat tolerance tests (blood taken fasting and for 8 h after a high-fat meal containing 80 g fat and 70 g carbohydrate). On the afternoon before one test, subjects performed a 90-min treadmill walk (exercise); no exercise was performed before the control test. Endothelium-dependent and -independent microvascular function was assessed using laser Doppler imaging in the fasted state and at two hourly intervals during the 8-h postprandial period. Results: Exercise reduced both fasting and postprandial triglyceride concentrations by 25% in both the lean and centrally obese groups (p < 0.0005). For all subjects taken together, exercise improved fasting endothelium-dependent function by 25% (p < 0.05), and, although there was a significant postprandial decrease in both endothelium-dependent and -independent function in both the control and exercise trials (p < 0.01), postprandial endothelium-dependent and -independent function were 15% and 20% higher, respectively, in the exercise trial than the control trial (both p < 0.05). Conclusions: A session of prior exercise improves fasting and postprandial vascular function in middle-aged men. This may be one mechanism by which exercise influences cardiovascular risk. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
07351097
Volume :
44
Issue :
12
Database :
Academic Search Index
Journal :
Journal of the American College of Cardiology (JACC)
Publication Type :
Academic Journal
Accession number :
15647169
Full Text :
https://doi.org/10.1016/j.jacc.2004.09.035