乳酸菌阴道胶囊联合重组人干扰素α-2b凝胶对宫颈高危型人乳头瘤病毒感染患者阴道微生态和炎症因子的影响.

Objective: To investigate the efficacy of Lactobacillus vaginal capsule combined with recombinant human interferonα-2b gel in the treatment of high-risk cervical human papillomavirus (HR-HPV) infection and its effects on vaginal microecology and inflammatory factors. Methods: 94 patients with cervical HR-HPV infection who were treated in our hospital from March 2019 to March2021 were randomly divided into control group (n=47) and study group (n=47) by the random number table method. The patients in the control group were treated with recombinant human interferon α-2b gel, and patients in the study group were combined with Lactobacillus vaginal capsule on this basis. The efficacy, vaginal microecology, inflammatory factors, HPV-DNA viral load and HPV-DNA negative conversion rate of the two groups after treatment were observed, and the drug safety of the two groups was observed. Results: The clinical total effective rate of the study group (89.36%) was higher than (65.96%) of the control group (P<0.05). The pH of vaginal secretion and Nugent score of the study group were lower than those of the control group, and the normal or recovery rates of vaginal Microecology were higher than those of the control group (P<0.05). After treatment, the serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and C-reactive protein (CRP) of the two groups were lower than those before treatment, and the study group was lower than the control group(P<0.05). After treatment, the HPV-DNA viral load of the two groups was lower than that before treatment, and the study group was lower than the control group (P<0.05). The HPV-DNA negative conversion rate of the study group was higher than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Based on the treatment of recombinant human interferon α-2b gel combined with Lactobacillus vaginal capsule for patients with cervical HR-HPV infection, it can promote the recovery of vaginal microecology, effectively control HPV infection, reduce the level of inflammatory factors in patients, and the efficacy is reliable. [ABSTRACT FROM AUTHOR]