Efficacy of nilotinib in monozygotic twins with spinocerebellar ataxia type 6.

Nilotinib has also shown an efficacy for various cerebellar ataxias [[6]], Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB) [[8]], and Alzheimer's disease (AD) [[12]]. Dear Sirs, Mutations of the cluster-Abelson (c-Abl) may lead to an enhanced protein kinase activity, increased cell proliferation, and chronic myeloid leukemia (CML). Left vertical axis indicates the scores of activity of daily living (ADL), dizziness handicap inventory (DHI), and the scale for the rating and assessment of ataxia (SARA). [Extracted from the article]