Back to Search
Start Over
A combination of polarity reversal, Diels-Alder cycloaddition and skeletal remodeling to access pyridine-fused nitrones.
- Source :
-
Chemical Communications . 4/18/2022, Vol. 58 Issue 30, p4775-4778. 4p. - Publication Year :
- 2022
-
Abstract
- An unprecedented cascade strategy consisting of polarity reversal, normal electron-demand Diels-Alder cycloaddition and skeletal remodeling was developed to construct novel pyridine-fused nitrones in up to 82% yield. The key to the success was the umpolung process, which transformed the electron-deficient 3-nitropyridinium ring into a reactive, p-extended cyclic nitroalkene, serving as a rarely reported hetero-diene to participate in normal Diels-Alder cycloadditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NITRONES
*UMPOLUNG
*DIELS-Alder reaction
*SUCCESS
*RING formation (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 30
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 156406103
- Full Text :
- https://doi.org/10.1039/d2cc00155a