Are ABO blood groups associated with premalignant gastric lesions and helicobacter pylori?

Introduction: ABO blood group, a genetically determined trait for Helicobacter pylori, has been considered as a potential risk factor. Blood groups have also been investigated as a risk factor for H. pylori-related stomach cancer. This study aimed to investigate the relationship between the ABO blood types and H. pylori positivity, H. pylori-related premalignant gastric lesions, age, and gender in people in the present region. Materials and Methods: Patients who went through endoscopy for various complaints, from whom biopsy was taken during the process, and who knew their blood type were included in the study. The demographic characteristics of the patients, their blood groups, and their place of residence were recorded. H. pylori positivity and premalignant gastric lesion conditions were determined by evaluating the pathology results. Results: A total of 160 patients, 81 (51%) of whom were female and 79 (49%) of whom were male, were included in the study. H. pylori positivity was found to be 59.2% in women and 37.9% in men, and the difference was statistically significant (P < 0.05). The blood group of 69 of the patients (43%) were A, 53 of the patients (33%) were 0, 29 of the patients (18%) were B, and nine of the patients (6%) were AB. There was no statistically significant difference between H. pylori positivity and ABO blood groups. The relationship between premalignant gastric lesions and blood groups was not statistically significant. Conclusion: This study showed that there was no significant relationship between ABO blood groups and H. pylori positivity and premalignant gastric lesions, while age and gender were important in H. pylori positivity. [ABSTRACT FROM AUTHOR]