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Synthesis And Preliminary Antimicrobial Evaluation Of Schiff Bases Of N-Benzyl Isatin Derivatives.
- Source :
-
Systematic Reviews in Pharmacy . 2020, Vol. 11 Issue 12, p1950-1955. 6p. - Publication Year :
- 2020
-
Abstract
- Isatin (1H-indole-2,3-dione) and its analogs are an important class of heterocyclic compounds. N-benzyl isatins and Schiff bases of isatin analogs have been reported to demonstrate a variety of biological activities. This work illustrates the synthesis of new N-benzylisatin Schiff bases and studies their biological activity. Firstly, Isatin and its analogs; 5-methoxyisatin, 5-fluoroisatin reacted with benzyl iodide to obtain N- benzylated derivatives of isatins 2(a-c). Secondly, these compounds were reacted with different amines (sulphanilamide and 4- methyl sulphonyl aniline) separately, to obtain Schiff bases compounds 3(a-c) and 4(a-c), respectively. The synthesized compounds were characterized by using FT-IR and 1HNMR spectroscopy. The synthesized Schiff bases 3(a-c) and 4(a-c) were examined for their in vitro antimicrobial activity using different Gram-positive bacteria, Gram-negative bacteria, and Candida albicans as fungi. The obtained results were compared with standard drugs: amoxicillin, ciprofloxacin, and fluconazole. All the compounds show no antifungal activity at any concentrations used, while most of them show moderate antibacterial activity at concentration 5mg/mL toward most bacteria except Klebsiella pneumonia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09758453
- Volume :
- 11
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Systematic Reviews in Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 156331800