卡贝缩宫素合Bakri球囊压迫对宫缩乏力性产后出血患者卵巢功能和凝血功能的影响.

To investigate the effects of carbetocin and Bakri balloon compression on ovarian function and coagulation function in patients with uterine asthenia postpartum hemorrhage. 86 patients with uterine asthenia postpartum hemorrhage who were treated in our hospital from February 2017 to March 2021 were selected, and they were randomly divided into control group and study group by random number table method. They were treated with Bakri balloon compression alone and carbetocin and Bakri balloon compression combined. Ovarian function indexes including luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E2) were detected and compared. The changes of diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate, bleeding volume and hemostasis onset time in two groups were recorded. Fibrinogen (FIB), prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured, the adverse reactions of the two groups were compared. The changes of DBP, SBP and heart rate in the two groups fluctuated little, and there was no significant difference after treatment (P>0.05). The bleeding volume at 2 h and 24 h after treatment in two groups decreased, and the bleeding volume and hemostasis onset time in the study group at 2 h and 24 h after treatment were shorter than those in the control group(P<0.05). 3 d after treatment, the level of FIB in the two groups decreased, and the levels of PT and APTT increased, and the level of FIB in the study group was lower than that in the control group, and the levels of PT and APPT were higher than those in the control group(P<0.05). 3 d after treatment, the levels of serum E2 in the two groups increased, and the levels of FSH and LH decreased, and the levels of serum E2, FSH and LH in the study group were better than those in the control group(P<0.05). The incidence of adverse reactions in the study group(8.89%) was higher than that in the control group (4.88%), but there was no significant difference (P>0.05). The combined treatment of carbetocin and Bakri balloon compression can effectively improve the ovarian function and coagulation function of patients with uterine asthenia postpartum hemorrhage, improve the postpartum hemostasis effect, and enhance the uterine contractility of patients. [ABSTRACT FROM AUTHOR]