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Role of inhibitory signaling in peripheral B cell tolerance*.
- Source :
-
Immunological Reviews . May2022, Vol. 307 Issue 1, p27-42. 16p. - Publication Year :
- 2022
-
Abstract
- At least 20% of B cells in the periphery expresses an antigen receptor with a degree of self‐reactivity. If activated, these autoreactive B cells pose a risk as they can contribute to the development of autoimmune diseases. To prevent their activation, both B cell‐intrinsic and extrinsic tolerance mechanisms are in place in healthy individuals. In this review article, I will focus on B cell‐intrinsic mechanisms that prevent the activation of autoreactive B cells in the periphery. I will discuss how inhibitory signaling circuits are established in autoreactive B cells, focusing on the Lyn‐SHIP‐1‐SHP‐1 axis, how they contribute to peripheral immune tolerance, and how disruptions of these circuits can contribute to the development of autoimmunity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01052896
- Volume :
- 307
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunological Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 156131643
- Full Text :
- https://doi.org/10.1111/imr.13070