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Immune phenotypic linkage between colorectal cancer and liver metastasis.
- Source :
-
Cancer Cell . Apr2022, Vol. 40 Issue 4, p424-424. 1p. - Publication Year :
- 2022
-
Abstract
- The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially influence the immune composition within TME. Here, we performed single-cell analyses for autologous samples from liver metastasized colorectal cancer to disentangle factors shaping TME. By aligning CD45+ cells across different tissues, we classified exhausted CD8+ T cells (Texs) and activated regulatory T cells as M-type, whose phenotypes were associated with the malignancy, while natural killer and mucosal-associated invariant T cells were defined as N-type, whose phenotypes were associated with the niche. T cell receptor sharing between Texs in primary and metastatic tumors implicated the presence of common peripheral non-exhausted precursors. For myeloid cells, a subset of dendritic cells (DC3s) and SPP1 + macrophages were M-type, and the latter were predominant in liver metastasis, indicating its pro-metastasis role. Our analyses bridge immune phenotypes of primary and metastatic tumors, thereby helping to understand the tumor-specific contexture and identify the pro-metastasis components. [Display omitted] • Immune cell phenotypic linkage with colorectal cancer and liver metastasis depicted • Malignancy-associated exhausted and regulatory T cells show diverse TCR dependency • SPP1 + TAMs are malignancy associated and are linked to liver metastasis • DCs are mainly associated with host organ except a malignancy-associated DC3 subset Liu et al. reveal the roles of malignancy and host-organ contexture in shaping immune infiltrates within a tumor microenvironment based on single-cell phenotypic alignment of colorectal cancer and the autologous liver metastasis [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 40
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 156128188
- Full Text :
- https://doi.org/10.1016/j.ccell.2022.02.013