Erectile Dysfunction with Topiramate.

This article focuses on erectile dysfunction with topiramate. The antiepileptic drug (AED) topiramate (TPM) is efficient in new-onset partial epilepsies as well as in refractory partial and generalized epilepsies. Several adverse events with this substance have been described; the most common and important include somnolence, fatigue, nausea, anorexia and weight loss, paresthesias, psychomotor slowing and confusion, dizziness, and headache. Interference with sexual function with TPM has not yet been reported. Two patients were recently encountered with partial epilepsy in whom reversible erectile dysfunction developed while taking TPM. The cases are described to draw attention to a distressing side effect of the drug.