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The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition.
- Source :
-
Cells Tissues Organs . 2022, Vol. 211 Issue 2, p134-156. 23p. - Publication Year :
- 2022
-
Abstract
- Despite substantial advances in the field of cancer therapeutics, metastasis is a significant challenge for a favorable clinical outcome. Epithelial to mesenchymal transition (EMT) is a process of acquiring increased motility, invasiveness, and therapeutic resistance by cancer cells for their sustained growth and survival. A plethora of intrinsic mechanisms and extrinsic microenvironmental factors drive the process of cancer metastasis. Calcium (Ca2+) signaling plays a critical role in dictating the adaptive metastatic cell behavior comprising of cell migration, invasion, angiogenesis, and intravasation. By modulating EMT, Ca2+ signaling can regulate the complexity and dynamics of events leading to metastasis. This review summarizes the role of Ca2+ signal remodeling in the regulation of EMT and metastasis in cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14226405
- Volume :
- 211
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cells Tissues Organs
- Publication Type :
- Academic Journal
- Accession number :
- 156057735
- Full Text :
- https://doi.org/10.1159/000512277