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MicroRNA-30c-2-3p targets STRIP2 to suppress malignant progression of gastric cancer cells.
- Source :
-
Journal of Biochemistry . Apr2022, Vol. 171 Issue 4, p451-457. 7p. - Publication Year :
- 2022
-
Abstract
- MicroRNA plays a crucial part in genesis and development of gastric cancer (GC). We uncovered that microRNA-30c-2-3p was down-regulated in GC tissue and cell lines. Suppression of microRNA-30c-2-3p promoted progression of GC cells in vitro. STRIP2 was confirmed as a target for microRNA-30c-2-3p. MicroRNA-30c-2-3p overexpression remarkably suppressed cell malignant behaviours, while reintroduction of STRIP2 partially restored the anticancer effect of microRNA-30c-2-3p. Taken together, these findings suggested that microRNA-30c-2-3p acted as a candidate tumour suppressor in GC by directly targeting STRIP2. Therefore, microRNA-30c-2-3p can be used as a towardly GC therapeutic target. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0021924X
- Volume :
- 171
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 156053981
- Full Text :
- https://doi.org/10.1093/jb/mvac006