2型糖尿病患者周围神经肌电图改变与临床指标及 病程相关性分析.

Objective To investigate the correlation between peripheral nerves electromyography (EMG) changes and clinical indicators [glycosylated hemoglobin（HbA1C）,high-density lipoprotein (HDL), urinary free cortisol] and disease course in patients with type 2 diabetes mellitus（T2DM) .Methods The correlation between the specific results of neuro EMG (sensory and motor nerves of lower limbs and autonomic nerves), clinical indicators [glycated hemoglobin（HbA1C）,HDL,urinary free cortisol]and disease course of 127 T2DM patients admitted to Huai’an First Hospital Affiliated to Nanjing Medical University from December 2020 to June 2021 was retrospectively analyzed. Results Urinary free cortisol was positively correlated with tibial nerve movement (ankle-AH) [left correlation coefficient (r) =0.209,P=0.019;right r=0.189,P=0.034].HDL was negatively correlated with tibial nerve movement (popliteal fossa-ankle) latency (Lat) (left r=-0.213,P=0.016;right r=-0.210,P=0.018）.HbA1C was positively correlated with tibial nerve motor (ankle-AH) Lat (left r=0.187,P=0.036;right r=0.187,P=0.035). There was a significant correlation between the disease course of diabetes mellitus and motor-sensory nerve damage, and this correlation was widely correlated with the types of peripheral nerve damage. Conclusion The disease course of T2DM,HbA1C,HDL and urinary cortisol are related to the changes of EMG in T2DM.Urinary-free cortisol is mainly related to nerve axonal damage, while HDL and HbA1C are mainly related to the nerve myelin sheath damage, disease course is mainly related to motor-sensory nerve damage. [ABSTRACT FROM AUTHOR]