Synthesis of α-CF3-substituted γ, δ -didehydro lysine derivatives.

[Display omitted] An efficient and selective access to novel α-CF 3 -substituted γ,δ-didehydro lysine derivatives and their phosphorus analogues has been developed via the Cu-catalyzed Mannich reaction of α-amino α-propargyl α-trifluoromethyl carboxylates or phosphonates with different secondary amines and paraformaldehyde. [ABSTRACT FROM AUTHOR]