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Urinary sodium/creatinine ratio is a predictor for fractional sodium excretion and related to age in patients with cystic fibrosis.
- Source :
-
Journal of Cystic Fibrosis . Mar2022, Vol. 21 Issue 2, pe136-e140. 5p. - Publication Year :
- 2022
-
Abstract
- • Patients with cystic fibrosis are prone to electrolyte disturbances. • Guidelines state to monitor sodium status. • Sodium/creatinine ratio is an excellent surrogate marker for fractional sodium excretion. • Cut-offs for sodium/creatinine ratio are age related. Electrolyte disturbances are common in patients with cystic fibrosis (CF). Current guidelines on monitoring sodium status are based on research in a small group of infants and require blood sampling. The aim of this study was to evaluate urinary salt parameters as a surrogate for sodium-status in different age-groups. Blood and urine samples for electrolytes were collected from 222 patients followed at the Ghent University Hospital CF-center. Fractional sodium excretion (FENa) and several urinary parameters were calculated. Clinical characteristics did not differ according to sodium status, defined as FENa <0.5%. ROC analysis demonstrated that sodium/creatinine ratio (UNa/Creat) predicted the sodium status most accurately with high sensitivity and specificity (97 and 91% respectively). The UNa/Creat cut-off predicting a FENa <0.5% differed significantly according to age. The UNa/Creat is an excellent marker for the sodium status defined as a FENa <0.5%. However, different cut-offs according to age category should be applied. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYSTIC fibrosis
*SODIUM
*CREATININE
*EXCRETION
*BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 15691993
- Volume :
- 21
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Cystic Fibrosis
- Publication Type :
- Academic Journal
- Accession number :
- 155886847
- Full Text :
- https://doi.org/10.1016/j.jcf.2021.11.002