Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive roles.

The suppressor of cytokine signaling 6 (SOCS6), an emerged important member of SOCS family, has attracted enhancing attention regarding its pivotal role in the development and progression of cancers. As part of negative feedback regulation, SOCS6 has been implicated in attenuating cytokine signal transduction via inhibiting the signaling cascade of activated cytokine receptors and multiple receptor tyrosine kinase signaling. Decreased SOCS6 expression is involved in diverse tumorigenic processes, such as abnormal cell proliferation, evasion of apoptosis, cancer migration, and cancer stem cell maintenance. Herein, this review summarized the mechanisms of SOCS6 regulation underlying multiple pathways. In particular, we focus on the pathological processes of cancer targeted by SOCS6 and discuss its inhibitory role during tumor progression. Also, we focused on the clinical relevance of SOCS6 in cancer biomarker and prognosis, as well as its significance in chemoresistance and radioresistance. In all, this review pave a way to assist in experimental designs and emphasize the potential clinical value of SOCS6 for cancer. [Display omitted] • SOCS6 prominently involves in inhibition of receptor tyrosine kinase signaling cascades. • SOCS6 overexpression participates in in cancer development, such as cell proliferation, apoptosis, and migration. • Reduced SOCS6 expression contributes to the tumorigenesis in in cancer of digestive, respiratory and hematological system. • SOCS6 overexpression may reverse the resistance of cancer cells to chemotherapy drugs or radiotherapy. • SOCS6 downregulation acts as independent prognostic factor of shorter OS and DFS in numerous cancer types. [ABSTRACT FROM AUTHOR]