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Adherence to a vegetable dietary pattern attenuates the risk of non‐alcoholic fatty liver disease in incident type 2 diabetes: The TCLSIH cohort study.
- Source :
-
Journal of Internal Medicine . Apr2022, Vol. 291 Issue 4, p469-480. 12p. - Publication Year :
- 2022
-
Abstract
- Background: Non‐alcoholic fatty liver disease (NAFLD) is a strong risk factor for type 2 diabetes. However, no study has investigated whether dietary intake can modify this effect. Therefore, we aimed to investigate the effect of dietary pattern modification on the association between NAFLD and type 2 diabetes. Methods: A large prospective cohort study (n = 24,602) was conducted in China. NAFLD was diagnosed using liver ultrasonography considering alcohol consumption. Dietary data were assessed using a validated self‐administered food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Following a 93,873 person‐year follow‐up, 787 (3.20%) participants developed type 2 diabetes. In a multivariable adjusted model, compared with participants without NAFLD, the HR (95% CI) of incident type 2 diabetes for NAFLD patients was 3.04 (2.51, 3.68). On subgroup analyses, the adjusted HRs (95% CIs) of incident type 2 diabetes for NAFLD patients with low (≤median score) and high (>median score) vegetable pattern intakes were 4.08 (3.05, 5.46) and 2.38 (1.85, 3.07) (p for interaction <0.01), respectively. Higher vegetable intake was also found to attenuate the risk effect of phenotype groups of NAFLD on incident type 2 diabetes, especially in the lean NAFLD group. Conclusions: The present study demonstrated that NAFLD is a strong risk factor for type 2 diabetes in the Chinese population. Notably, adherence to a dietary pattern rich in vegetables can attenuate this risk, especially in lean NAFLD patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NON-alcoholic fatty liver disease
*TYPE 2 diabetes
*COHORT analysis
*VEGETABLES
Subjects
Details
- Language :
- English
- ISSN :
- 09546820
- Volume :
- 291
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 155864241
- Full Text :
- https://doi.org/10.1111/joim.13428