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Virus-mediated GHS-R1a expression in the basolateral amygdala blocks extinction of conditioned taste aversion memory in rats.
- Source :
-
Biochemical & Biophysical Research Communications . Apr2022, Vol. 602, p57-62. 6p. - Publication Year :
- 2022
-
Abstract
- Ghrelin is an orexigenic gastric hormone that promotes feeding behaviors and regulating energy homeostasis in both humans and rodents. Our previous studies have shown that ghrelin, when locally infused into the basolateral amygdala (BLA), blocks both acquisition and extinction of conditioned taste aversion (CTA) memory in rats. In this study, we further investigated the effect of virus-mediated overexpression of ghrelin receptor growth hormone secretagogue receptor 1a (GHS-R1a) in BLA pyramidal neurons on CTA memory processes. We found that upregulation of GHS-R1a expression in BLA pyramidal neurons repressed CTA extinction while it had no effect on CTA acquisition. In addition, we reported that local infusion of the endogenous GHS-R1a antagonist, liver-expressed antimicrobial peptide 2 (LEAP2), in the BLA abolished the inhibitory effect of increased GHS-R1a on CTA memory extinction. Those findings provide new supportive evidence that ghrelin/GHS-R1a signaling in the BLA circuit shapes emotional memory processes. • GHS-R1a overexpression in BLA pyramidal neurons repressed CTA extinction. • GHS-R1a upregulation in BLA pyramidal neurons did not affect CTA acquisition. • LEAP2 treatment abolished the inhibition of high GHS-R1a on CTA extinction. • Ghrelin/GHS-R1a signaling in the BLA circuit shapes emotional memory processes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 602
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155861492
- Full Text :
- https://doi.org/10.1016/j.bbrc.2022.02.105