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Serum Levels of Interleukin 10, Interleukin 17A, and Calcitriol in Different Groups of Colorectal Cancer Patients.
- Source :
-
Jordan Journal of Biological Sciences . Mar2022, Vol. 15 Issue 1, p75-81. 7p. - Publication Year :
- 2022
-
Abstract
- Colorectal cancer (CRC) is considered as the fourth prevalent reason of cancer deaths. Interleukin 10 (IL10) and interleukin 17A (IL-17A) act as anti-inflammatory and pro-inflammatory cytokines, respectively, both being able to exert antitumor or pro-tumor roles in cancer. Serum levels for IL-10, IL-17A, and calcitriol were measured by ELISA. The CRC patient sample (n =90) consisted of newly diagnosed, before surgery, and after surgery groups, the results of which were compared with those of healthy subjects (n=30). IL-10 levels demonstrated significantly lower (P<0.001), significantly higher (P<0.001), and insignificant differences in the three groups, respectively, as compared to the control. Serum IL-17A levels were significantly higher (P<0.001) in all patient groups compared with healthy subjects, whereas calcitriol levels were significantly lower in most patients. In conclusion,low levels of IL-10 found in CRC patients at diagnosis could be used as a diagnostic marker for the disease. However, chemo-radiotherapy caused an increase in the levels of this cytokine, which were restored to normal following surgical intervention. In addition, a contribution of serum calcitriol in changing the levels of IL-10 in CRC patients was observed. High levels of IL-17A, regardless of patient group, indicated a strong association with CRC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CALCITRIOL
*COLORECTAL cancer
*CANCER patients
*INTERLEUKIN-10
*CHEMORADIOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 19956673
- Volume :
- 15
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Jordan Journal of Biological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 155850046
- Full Text :
- https://doi.org/10.54319/jjbs/150110