APOE gene polymorphism alters cerebral oxygen saturation and quantitative EEG in early-stage traumatic brain injury.

[Display omitted] • The regional cerebral oxygen saturation (rScO 2) and quantitative electroencephalogram (QEEG) were significantly changed at the early stage of TBI patients. • The APOE ε4 allele may lead to deterioration of rScO 2 and QEEG at the early stage of TBI patients. • The relationships between APOE gene polymorphism and rScO 2 and QEEG at an early stage of TBI are important and worth further studying. To investigate the influence of apolipoprotein E (APOE) gene polymorphism on regional cerebral oxygen saturation (rScO 2) and quantitative electroencephalogram (QEEG) at the early phase of adult traumatic brain injury (TBI). clinical data of TBI patients who were admitted to the neurosurgery intensive care unit (NICU) were retrospectively evaluated and studied, and data of healthy volunteers were recruited as control. The APOE genotypes were genotyped by quantitative fluorescent polymerase chain reaction (QF-PCR). The rScO 2 and brain electrical activity of all the participants involved in this research were measured by near-infrared spectroscopy (NIRS) and QEEG respectively. The average rScO 2 of TBI patients was significantly lower than that of the normal controls (P < 0.0001). And the EEG of the TBI patients has showed more irregular slow-wave activities than that of the normal controls. Furthermore, the above changes were more significant in the APOE ε4 carriers in the early stage of TBI patients. The APOE ε4 allele may be associated with poor rScO 2 and more slow-wave activities at the early stage of TBI. To clarify the effect of APOE gene polymorphism on the condition of patients with TBI may be helpful for the design and management of individualized treatment programs. [ABSTRACT FROM AUTHOR]