Comparative In Vitro Anticancer Study Of 4-Thiazolidinone Scaffold Bearing Thiadiazole Moiety Derived from Phenolic Aldehydes.

A series of newly synthesized analogs (10a-y) were prepared from phenolic aldehydes such as Vanillin and salicaldehyde. The synthesized analogs were characterized by using different spectral techniques such as FTIR, ¹NMR, 13C NMR and Mass spectroscopy and evaluated against In vitro cancer cell lines such as MCF-7 and HeLa. The result achieved depicted that the phenolic aldehyde vanillin bearing electron donating substituent's exhibited more promising results as compared to salicaldehyde (Phenolic aldehyde). The comparative study of anticancer evaluation based on the in vitro study, which clearly signified that vanillin structure has OCH3 (Methoxy group) which is different from salicaldehyde (Which doesn't contain methoxy group). This difference based on the presence of electron donating group methoxy (OCH3) displayed the remarkable anticancer results. This research article based on the comparative anticancer study of 4-Thiazolidinone having thiadiazole moiety derived from two different phenolic aldehydes like Vanillin and salicaldehyde against cancer cell lines such as MCF-7 and HeLa. [ABSTRACT FROM AUTHOR]