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Potassium tert-butoxide promoted regioselective deuteration of pyridines.
- Source :
-
Chemical Communications . 3/14/2022, Vol. 58 Issue 21, p3497-3500. 4p. - Publication Year :
- 2022
-
Abstract
- A regioselective deuteration at the β- and γ-position of pyridines is reported. Efficient deuteration occurred with a combination of KOtBu and DMSO-d6, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DEUTERATION
*POTASSIUM
*CARBANIONS
*PYRIDINE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155685182
- Full Text :
- https://doi.org/10.1039/d1cc07128a