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KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation.

Authors :
Zhen Jiang
Elsarrag, Selma Z.
Qiming Duan
LaGory, Edward L.
Zhe Wang
Alexanian, Michael
McMahon, Sarah
Rulifson, Ingrid C.
Winchester, Sarah
Yi Wang
Vaisse, Christian
Brown, Jonathan D.
Quattrocelli, Mattia
Lin, Charles Y.
Haldar, Saptarsi M.
Source :
Science Advances. 3/11/2022, Vol. 8 Issue 10, p1-17. 17p.
Publication Year :
2022

Abstract

The article presents a study which explores how KLF15 (Kruppel-like factor 15) cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. It provide critical mechanistic insight into KLF15 function and identify a hepatocyte-intrinsic transcriptional module that potently regulates systemic corticosteroid transport and inflammation.

Details

Language :
English
ISSN :
23752548
Volume :
8
Issue :
10
Database :
Academic Search Index
Journal :
Science Advances
Publication Type :
Academic Journal
Accession number :
155673093
Full Text :
https://doi.org/10.1126/sciadv.abj2917